Publications

Selected publications

Please follow our latest publications in TUHAT or PubMed

Munne, Pauliina M.; Martikainen, Lahja; Räty, Iiris; Bertula, Kia; Nonappa; Ruuska, Janika; Ala-Hongisto, Hanna; Peura, Aino; Hollmann, Babette; Euro, Lilya; Yavuz, Kerim; Patrikainen, Linda; Salmela, Maria; Pokki, Juho; Kivento, Mikko; Väänänen, Juho; Suomi, Tomi; Nevalaita, Liina; Mutka, Minna; Kovanen, Panu; Leidenius, Marjut; Meretoja, Tuomo; Hukkinen, Katja; Monni, Outi; Pouwels, Jeroen; Sahu, Biswajyoti; Mattson, Johanna; Joensuu, Heikki; Heikkilä, Päivi; Elo, Laura L.; Metcalfe, Ciara; Junttila, Melissa R.; Ikkala, Olli; Klefström, Juha.
Compressive stress-mediated p38 activation required for ERα + phenotype in breast cancer Nature Communications :, 2021.

Topi A Tervonen , Shishir M Pant , Denis Belitškin, Johanna I Englund, Katja Närhi, Caj Haglund, Panu E Kovanen, Emmy W Verschuren, Juha Klefström.
Oncogenic Ras disrupts epithelial integrity by activating the transmembrane serine protease hepsin Cancer Research :, 2021.

Haikala HM, Anttila JM, Marques E, Raatikainen T, Ilander M, Hakanen H, Ala-Hongisto H, Savelius M, Balboa D, Von Eyss B, Eskelinen V, Munne P, Nieminen AI, Otonkoski T, Schüler J, Laajala TD, Aittokallio T, Sihto H, Mattson J, Heikkilä P, Leidenius M, Joensuu H, Mustjoki S, Kovanen P, Eilers M, Leverson JD, Klefström J.
Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy. Nature communications 1:620, 2019.

Partanen JI, Nieminen AI, Mäkelä TP, Klefstrom J.
Suppression of oncogenic properties of c-Myc by LKB1-controlled epithelial organization. Proceedings of the National Academy of Sciences of the United States of America 37:14694-9, 2007.

Werner S, Brors B, Eick J, Marques E, Pogenberg V, Parret A, Kemming D, Wood AW, Edgren H, Neubauer H, Streichert T, Riethdorf S, Bedi U, Baccelli I, Jücker M, Eils R, Fehm T, Trumpp A, Johnsen SA, Klefström J, Wilmanns M, Müller V, Pantel K, Wikman H.
Suppression of early hematogenous dissemination of human breast cancer cells to bone marrow by retinoic Acid-induced 2. Cancer discovery 5:506-19, 2015.

Nieminen AI, Eskelinen VM, Haikala HM, Tervonen TA, Yan Y, Partanen JI, Klefström J.
Myc-induced AMPK-phospho p53 pathway activates Bak to sensitize mitochondrial apoptosis. Proceedings of the National Academy of Sciences of the United States of America 20:E1839-48, 2013.

Partanen JI, Tervonen TA, Myllynen M, Lind E, Imai M, Katajisto P, Dijkgraaf GJ, Kovanen PE, Mäkelä TP, Werb Z, Klefström J.
Tumor suppressor function of Liver kinase B1 (Lkb1) is linked to regulation of epithelial integrity. Proceedings of the National Academy of Sciences of the United States of America 7:E388-97, 2012.

Haikala HM, Klefström J, Eilers M, Wiese KE.
MYC-induced apoptosis in mammary epithelial cells is associated with repression of lineage-specific gene signatures. Cell cycle (Georgetown, Tex.) 3:316-23, 2016.

Myant K, Qiao X, Halonen T, Come C, Laine A, Janghorban M, Partanen JI, Cassidy J, Ogg EL, Cammareri P, Laiterä T, Okkeri J, Klefström J, Sears RC, Sansom OJ, Westermarck J.
Serine 62-Phosphorylated MYC Associates with Nuclear Lamins and Its Regulation by CIP2A Is Essential for Regenerative Proliferation. Cell reports 6:1019-31, 2015.

Marques E, Englund JI, Tervonen TA, Virkunen E, Laakso M, Myllynen M, Mäkelä A, Ahvenainen M, Lepikhova T, Monni O, Hautaniemi S, Klefström J.
Par6G suppresses cell proliferation and is targeted by loss-of-function mutations in multiple cancers. Oncogene 11:1386-98, 2016.

Wiese KE, Haikala HM, von Eyss B, Wolf E, Esnault C, Rosenwald A, Treisman R, Klefström J, Eilers M.
Repression of SRF target genes is critical for Myc-dependent apoptosis of epithelial cells. The EMBO journal 11:1554-71, 2015.

Tervonen TA, Belitškin D, Pant SM, Englund JI, Marques E, Ala-Hongisto H, Nevalaita L, Sihto H, Heikkilä P, Leidenius M, Hewitson K, Ramachandra M, Moilanen A, Joensuu H, Kovanen PE, Poso A, Klefström J.
Deregulated hepsin protease activity confers oncogenicity by concomitantly augmenting HGF/MET signalling and disrupting epithelial cohesion. Oncogene 14:1832-46, 2016.

Louhimo R, Laakso M, Belitskin D, Klefström J, Lehtonen R, Hautaniemi S.
Data integration to prioritize drugs using genomics and curated data. BioData mining :21, 2016.

Full list of publications

Please follow our latest publications in TUHAT or PubMed

2021

Filippou A, Pehkonen H, Karhemo PR, Väänänen J, Nieminen AI, Klefström J, Grénman R, Mäkitie AA, Joensuu H, Monni O.
ANO1 Expression Orchestrates p27Kip1/MCL1-Mediated Signaling in Head and Neck Squamous Cell Carcinoma. Cancers 5:, 2021.

Belitškin D, Pant SM, Munne P, Suleymanova I, Belitškina K, Hongisto HA, Englund J, Raatikainen T, Klezovitch O, Vasioukhin V, Li S, Wu Q, Monni O, Kuure S, Laakkonen P, Pouwels J, Tervonen TA, Klefström J.
Hepsin regulates TGFβ signaling via fibronectin proteolysis. EMBO reports :e52532, 2021.

2020

Utz B, Turpin R, Lampe J, Pouwels J, Klefström J..
Assessment of the WAP-Myc mouse mammary tumor model for spontaneous metastasis Scientific Reports :, 2020.

Qiao X, Liu Y, Llamazares Prada M, Mohan AK, Gupta A, Jaiswal A, Sharma M, Merisaari J, Haikala HM, Talvinen K, Yetukuri L, Pylvänäinen JW, Klefström J, Kronqvist P, Meinander A, Aittokallio T, Hietakangas V, Eilers M, Westermarck J.
UBR5 is co-amplified with MYC in breast tumors and encodes an ubiquitin ligase that limits MYC-dependent apoptosis. Cancer research :, 2020.

2019

Damalanka VC, Han Z, Karmakar P, O'Donoghue AJ, La Greca F, Kim T, Pant SM, Helander J, Klefström J, Craik CS, Janetka JW.
Discovery of Selective Matriptase and Hepsin Serine Protease Inhibitors: Useful Chemical Tools for Cancer Cell Biology. Journal of medicinal chemistry 2:480-490, 2019.

2018

Marques E, Peltola T, Kaski S, Klefström J.
Phenotype-driven identification of epithelial signalling clusters. Scientific reports 1:4034, 2018.

Pant SM, Mukonoweshuro A, Desai B, Ramjee MK, Selway CN, Tarver GJ, Wright AG, Birchall K, Chapman TM, Tervonen TA, Klefström J.
Design, Synthesis, and Testing of Potent, Selective Hepsin Inhibitors via Application of an Automated Closed-Loop Optimization Platform. Journal of medicinal chemistry 10:4335-4347, 2018.

Pant SM, Belitskin D, Ala-Hongisto H, Klefström J, Tervonen TA.
Analyzing the Type II Transmembrane Serine Protease Hepsin-Dependent Basement Membrane Remodeling in 3D Cell Culture. Methods in molecular biology (Clifton, N.J.) :169-178, 2018.

2017

Haikala HM, Anttila JM, Klefström J.
MYC and AMPK-Save Energy or Die! Frontiers in cell and developmental biology :38, 2017.

2016

Haikala HM, Marques E, Turunen M, Klefström J.
Myc requires RhoA/SRF to reprogram glutamine metabolism. Small GTPases :1-9, 2016.

Louhimo R, Laakso M, Belitskin D, Klefström J, Lehtonen R, Hautaniemi S.
Data integration to prioritize drugs using genomics and curated data. BioData mining :21, 2016.

2015

Marques E, Klefström J.
Par6 family proteins in cancer. Oncoscience 11:894-5, 2015.

2014

Hickman JA, Graeser R, de Hoogt R, Vidic S, Brito C, Gutekunst M, van der Kuip H, IMI PREDECT Consortium..
Three-dimensional models of cancer for pharmacology and cancer cell biology: capturing tumor complexity in vitro/ex vivo. Biotechnology journal 9:1115-28, 2014.

2013

Khanna A, Kauko O, Böckelman C, Laine A, Schreck I, Partanen JI, Szwajda A, Bormann S, Bilgen T, Helenius M, Pokharel YR, Pimanda J, Russel MR, Haglund C, Cole KA, Klefström J, Aittokallio T, Weiss C, Ristimäki A, Visakorpi T, Westermarck J.
Chk1 targeting reactivates PP2A tumor suppressor activity in cancer cells. Cancer research 22:6757-69, 2013.

Partanen JI, Tervonen TA, Klefström J.
Breaking the epithelial polarity barrier in cancer: the strange case of LKB1/PAR-4. Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1629:20130111, 2013.

2012

Partanen JI, Klefstrom J.
Impact of epithelial organization on Myc expression and activity–letter. Cancer research 4:1035; author reply 1036, 2012.

2011

Tervonen TA, Partanen JI, Saarikoski ST, Myllynen M, Marques E, Paasonen K, Moilanen A, Wohlfahrt G, Kovanen PE, Klefstrom J.
Faulty epithelial polarity genes and cancer. Advances in cancer research :97-161, 2011.

2010

Kyrönlahti A, Kauppinen M, Lind E, Unkila-Kallio L, Butzow R, Klefström J, Wilson DB, Anttonen M, Heikinheimo M.
GATA4 protects granulosa cell tumors from TRAIL-induced apoptosis. Endocrine-related cancer 3:709-17, 2010.

Jääskeläinen M, Nieminen A, Pökkylä RM, Kauppinen M, Liakka A, Heikinheimo M, Vaskivuo TE, Klefström J, Tapanainen JS.
Regulation of cell death in human fetal and adult ovaries–role of Bok and Bcl-X(L). Molecular and cellular endocrinology 1-2:17-24, 2010.

2009

Rajecki M, af Hällström T, Hakkarainen T, Nokisalmi P, Hautaniemi S, Nieminen AI, Tenhunen M, Rantanen V, Desmond RA, Chen DT, Guse K, Stenman UH, Gargini R, Kapanen M, Klefström J, Kanerva A, Pesonen S, Ahtiainen L, Hemminki A.
Mre11 inhibition by oncolytic adenovirus associates with autophagy and underlies synergy with ionizing radiation. International journal of cancer 10:2441-9, 2009.

Partanen JI, Nieminen AI, Klefstrom J.
3D view to tumor suppression: Lkb1, polarity and the arrest of oncogenic c-Myc. Cell cycle (Georgetown, Tex.) 5:716-24, 2009.

2008

Heinonen H, Nieminen A, Saarela M, Kallioniemi A, Klefström J, Hautaniemi S, Monni O.
Deciphering downstream gene targets of PI3K/mTOR/p70S6K pathway in breast cancer. BMC genomics :348, 2008.

2007

Nieminen AI, Partanen JI, Hau A, Klefstrom J.
c-Myc primed mitochondria determine cellular sensitivity to TRAIL-induced apoptosis. The EMBO journal 4:1055-67, 2007.

Nieminen AI, Partanen JI, Klefstrom J.
c-Myc blazing a trail of death: coupling of the mitochondrial and death receptor apoptosis pathways by c-Myc. Cell cycle (Georgetown, Tex.) 20:2464-72, 2007.

2003

Klefström J, Alitalo K.
[Lentiviruses to use]. Duodecim; laaketieteellinen aikakauskirja 20:1917-9, 2003.

2002

Verschuren EW, Klefstrom J, Evan GI, Jones N.
The oncogenic potential of Kaposi’s sarcoma-associated herpesvirus cyclin is exposed by p53 loss in vitro and in vivo. Cancer cell 3:229-41, 2002.

Klefstrom J, Verschuren EW, Evan G.
c-Myc augments the apoptotic activity of cytosolic death receptor signaling proteins by engaging the mitochondrial apoptotic pathway. The Journal of biological chemistry 45:43224-32, 2002.

1999

Klefstrom J, Kovanen PE, Somersalo K, Hueber AO, Littlewood T, Evan GI, Greenberg AH, Saksela E, Timonen T, Alitalo K.
c-Myc and E1A induced cellular sensitivity to activated NK cells involves cytotoxic granules as death effectors. Oncogene 13:2181-8, 1999.

1998

Kinnula VL, Aito H, Klefstrom J, Alitalo K, Raivio KO.
Similarities between TNF and exogenous oxidants on the cytotoxic response of c-Myc-expressing fibroblasts in vitro. Cancer letters 1-2:191-8, 1998.

1997

Klefstrom J, Arighi E, Littlewood T, Jäättelä M, Saksela E, Evan GI, Alitalo K.
Induction of TNF-sensitive cellular phenotype by c-Myc involves p53 and impaired NF-kappaB activation. The EMBO journal 24:7382-92, 1997.

Enholm B, Paavonen K, Ristimäki A, Kumar V, Gunji Y, Klefstrom J, Kivinen L, Laiho M, Olofsson B, Joukov V, Eriksson U, Alitalo K.
Comparison of VEGF, VEGF-B, VEGF-C and Ang-1 mRNA regulation by serum, growth factors, oncoproteins and hypoxia. Oncogene 20:2475-83, 1997.

Monni O, Joensuu H, Franssila K, Klefstrom J, Alitalo K, Knuutila S.
BCL2 overexpression associated with chromosomal amplification in diffuse large B-cell lymphoma. Blood 3:1168-74, 1997.

1994

Knuutila S, Klefström J, Szymanska J, Lakkala T, Peltomäki P, Eray M, Teerenhovi L, Elonen E, Franssila KO, Kaartinen M.
Two novel human B-cell lymphoma lines of lymphatic follicle origin: cytogenetic, molecular genetic and histopathological characterisation. European journal of haematology 2:65-72, 1994.

Klefstrom J, Franssila K, Peltomäki P, Kaartinen M, Solin ML, Knuutila S.
Major and minor breakpoint sites of chromosomal translocation t(14;18) in subtypes of non-Hodgkin’s lymphomas. Leukemia research 4:245-50, 1994.

Klefstrom J, Västrik I, Saksela E, Valle J, Eilers M, Alitalo K.
c-Myc induces cellular susceptibility to the cytotoxic action of TNF-alpha. The EMBO journal 22:5442-50, 1994.

Västrik I, Mäkelä TP, Koskinen PJ, Klefstrom J, Alitalo K.
Myc protein: partners and antagonists. Critical reviews in oncogenesis 1:59-68, 1994.

1993

Klefstrom J, Koskinen PJ, Saksela E, Jäättelä M, Bravo R, Alitalo K.
A sub-set of immediate early mRNAs induced by tumor necrosis factor-alpha during cellular cytotoxic and non-cytotoxic responses. International journal of cancer 4:655-9, 1993.

1992

Klefström J, Saksela E, Alitalo K.
[Complex mechanics of tumor-necrosis-factor-induced cell death]. Duodecim; laaketieteellinen aikakauskirja 17:1449-55, 1992.

1990

Klefström J, Kaartinen M, Peltomäki P, Solin ML, Franssila K, Knuutila S.
[The use of polymerase chain reaction in the diagnosis of non-Hodgkin’s lymphoma]. Duodecim; laaketieteellinen aikakauskirja 23-24:1645-53, 1990.

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