Publications
Find our publications via the links below.
Top 10 – Most Important Publications
- Lee JV, Housley F, Yau C, Nakagawa R, Winkler J, Anttila JM, Munne PM, Savelius M, Houlahan KE, Van de Mark D, Hemmati G, Hernandez, GA, Zhang, Y, Samson S, Baas C, Esserman LJ, Van’t Veer L, Rugo HS, Curtis C, Klefström J, Matloubian M, Goga A. Combinatorial immunotherapies overcome MYC-driven immune evasion. Nature Commun., 13(1):3671, 2022. IF: 14.919, Cited: 3
Second to Nature among the NPGs multidisciplinary journals - Munne P, Martikainen L, Räty I, Bertula K, Nonappa N, Ruuska J, Ala-Hongisto H, Peura A, Hollmann B, Euro L, Yavuz K, Patrikainen L, Salmela M, Pokki J, Kivento M, Vaananen J, Suomi T, Nevalaita L, Mutka M, Kovanen P, Leidenius M, Meretoja T, Hukkinen K, Monni O, Pouwels J, Sahu B, Mattson J, Joensuu H, Heikkilä P, Elo L, Metcalfe C, Junttila M, Ikkala O, Klefström J. Compressive Stress-Mediated p38 Activation Required for ERα+ Phenotype in Breast Cancer. Nature Commun., 12(1):6967, 2021 IF: 14.919, Cited: 8
- Belitškin D, Pant SM, Munne P, Suleymanova I, Belitškina K, Ala-Hongisto H, Englund J, Raatikainen T, Klezovitch O, Vasioukhin V, Li S, Wu Q, Monni O, Kuure S, Laakkonen P, Pouwels J, Tervonen TA, Klefström J. Hepsin regulates TGFb signaling via fibronectin proteolysis. EMBO Rep., 22(11):e52532,2021 IF: 8.800, Cited: 2
- Tervonen TA, Pant S, Belitškin D, Englund JI, Närhi K, Haglund C, Kovanen PE, Verschuren E, Klefström J. Oncogenic Ras disrupts epithelial integrity by activating the transmembrane serine protease hepsin. Cancer Res. 81 (6):1513, 2021 IF: 12.701 (2021), Cited: 0
- Qiao X, Liu Y, Prada M, Mohan A, Gupta A, Jaiswal A, Sharma M, Merisaari J, Haikala H, Talvinen K, Yetukuri L, Pylvänäinen J, Klefström J, Kronqvist P, Meinander A, Aittokallio T, Hietakangas V, Eilers M, and Westermarck J. UBR5 is co-amplified with MYC in breast tumors and encodes an ubiquitin ligase that limits MYC-dependent apoptosis. Cancer Res. 80:1414, 2020 IF: 12.701 (2021), Cited: 18
- Bertula K, Martikainen L, Munne P, Hietala S, Klefström J, Ikkala O, Nonappa. Strain-Stiffening of Agarose Gels. ACS Macro Letters. 8(6):670, 2019
IF: 6.430 (highest IF journal in the field of polymer science), Cited: 45 - Haikala HM, Anttila JM, Marques E, Raatikainen T, Ilander M, Hakanen H, Ala-Hongisto H, Savelius M, Balboa D, Von Eyss B, Eskelinen V, Munne P, Nieminen AI, Otonkoski T, Schüler J, Laajala TD, Aittokallio T, Sihto H, Mattson J, Heikkilä P, Leidenius M, Joensuu H, Mustjoki S, Kovanen P, Eilers M, Leverson JD, Klefström J. Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy. Nature Commun. 10(1):620, 2019 IF: 14.919, Cited: 45
- Damalanka V, Han Z, Karmakar P, O’Donoghue A, La Greca F, Kim T, Pant S, Helander J, Klefström J, Craik C, Janetka J. Discovery of Selective Matriptase and Hepsin Serine Protease Inhibitors: Useful Chemical Tools for Cancer Cell Biology. J Med Chem. 62(2):480, 2019
IF: 7.446, Cited: 17
Ranks 3rd out of 59 journals in the category “Chemistry, Medicinal - Pant SM, Mukonoweshuro A, Desai B, Ramjee MK, Selway CN, Tarver GJ, Wright AG, Birchall K, Chapman TM, Tervonen TA, Klefström J. Design, synthesis and testing of potent, selective hepsin inhibitors via application of an automated closed-loop optimization platform. J Med Chem. 61(10): 4335, 2018 IF: 7.446, Cited: 22
- Haikala H, Marques E, Turunen M, Klefström J. Myc requires RhoA/SRF to reprogram glutamine metabolism. Small GTPases. 9:274-282, 2018 IF: 3.160, Cited: 15