Publications / Klefström lab

Publications

Selected publications

Tervonen TA, Belitškin D, Pant SM, Englund JI, Marques E, Ala-Hongisto H, Nevalaita L, Sihto H, Heikkilä P, Leidenius M, Hewitson K, Ramachandra M, Moilanen A, Joensuu H, Kovanen PE, Poso A, Klefström J.
Deregulated hepsin protease activity confers oncogenicity by concomitantly augmenting HGF/MET signalling and disrupting epithelial cohesion. Oncogene 14:1832-46, 2016.
Wiese KE, Haikala HM, von Eyss B, Wolf E, Esnault C, Rosenwald A, Treisman R, Klefström J, Eilers M.
Repression of SRF target genes is critical for Myc-dependent apoptosis of epithelial cells. The EMBO journal 11:1554-71, 2015.
Partanen JI, Tervonen TA, Myllynen M, Lind E, Imai M, Katajisto P, Dijkgraaf GJ, Kovanen PE, Mäkelä TP, Werb Z, Klefström J.
Tumor suppressor function of Liver kinase B1 (Lkb1) is linked to regulation of epithelial integrity. Proceedings of the National Academy of Sciences of the United States of America 7:E388-97, 2012.
Louhimo R, Laakso M, Belitskin D, Klefström J, Lehtonen R, Hautaniemi S.
Data integration to prioritize drugs using genomics and curated data. BioData mining :21, 2016.
Haikala HM, Klefström J, Eilers M, Wiese KE.
MYC-induced apoptosis in mammary epithelial cells is associated with repression of lineage-specific gene signatures. Cell cycle (Georgetown, Tex.) 3:316-23, 2016.
Marques E, Englund JI, Tervonen TA, Virkunen E, Laakso M, Myllynen M, Mäkelä A, Ahvenainen M, Lepikhova T, Monni O, Hautaniemi S, Klefström J.
Par6G suppresses cell proliferation and is targeted by loss-of-function mutations in multiple cancers. Oncogene 11:1386-98, 2016.
Partanen JI, Nieminen AI, Mäkelä TP, Klefstrom J.
Suppression of oncogenic properties of c-Myc by LKB1-controlled epithelial organization. Proceedings of the National Academy of Sciences of the United States of America 37:14694-9, 2007.
Nieminen AI, Eskelinen VM, Haikala HM, Tervonen TA, Yan Y, Partanen JI, Klefström J.
Myc-induced AMPK-phospho p53 pathway activates Bak to sensitize mitochondrial apoptosis. Proceedings of the National Academy of Sciences of the United States of America 20:E1839-48, 2013.
Werner S, Brors B, Eick J, Marques E, Pogenberg V, Parret A, Kemming D, Wood AW, Edgren H, Neubauer H, Streichert T, Riethdorf S, Bedi U, Baccelli I, Jücker M, Eils R, Fehm T, Trumpp A, Johnsen SA, Klefström J, Wilmanns M, Müller V, Pantel K, Wikman H.
Suppression of early hematogenous dissemination of human breast cancer cells to bone marrow by retinoic Acid-induced 2. Cancer discovery 5:506-19, 2015.
Myant K, Qiao X, Halonen T, Come C, Laine A, Janghorban M, Partanen JI, Cassidy J, Ogg EL, Cammareri P, Laiterä T, Okkeri J, Klefström J, Sears RC, Sansom OJ, Westermarck J.
Serine 62-Phosphorylated MYC Associates with Nuclear Lamins and Its Regulation by CIP2A Is Essential for Regenerative Proliferation. Cell reports 6:1019-31, 2015.

Full list of publications

TUHAT

2017

Haikala HM, Anttila JM, Klefström J.
MYC and AMPK-Save Energy or Die! Frontiers in cell and developmental biology :38, 2017.

2016

Haikala HM, Marques E, Turunen M, Klefström J.
Myc requires RhoA/SRF to reprogram glutamine metabolism. Small GTPases :1-9, 2016.
Louhimo R, Laakso M, Belitskin D, Klefström J, Lehtonen R, Hautaniemi S.
Data integration to prioritize drugs using genomics and curated data. BioData mining :21, 2016.
Haikala HM, Klefström J, Eilers M, Wiese KE.
MYC-induced apoptosis in mammary epithelial cells is associated with repression of lineage-specific gene signatures. Cell cycle (Georgetown, Tex.) 3:316-23, 2016.
Marques E, Englund JI, Tervonen TA, Virkunen E, Laakso M, Myllynen M, Mäkelä A, Ahvenainen M, Lepikhova T, Monni O, Hautaniemi S, Klefström J.
Par6G suppresses cell proliferation and is targeted by loss-of-function mutations in multiple cancers. Oncogene 11:1386-98, 2016.
Tervonen TA, Belitškin D, Pant SM, Englund JI, Marques E, Ala-Hongisto H, Nevalaita L, Sihto H, Heikkilä P, Leidenius M, Hewitson K, Ramachandra M, Moilanen A, Joensuu H, Kovanen PE, Poso A, Klefström J.
Deregulated hepsin protease activity confers oncogenicity by concomitantly augmenting HGF/MET signalling and disrupting epithelial cohesion. Oncogene 14:1832-46, 2016.

2015

Marques E, Klefström J.
Par6 family proteins in cancer. Oncoscience 11:894-5, 2015.
Myant K, Qiao X, Halonen T, Come C, Laine A, Janghorban M, Partanen JI, Cassidy J, Ogg EL, Cammareri P, Laiterä T, Okkeri J, Klefström J, Sears RC, Sansom OJ, Westermarck J.
Serine 62-Phosphorylated MYC Associates with Nuclear Lamins and Its Regulation by CIP2A Is Essential for Regenerative Proliferation. Cell reports 6:1019-31, 2015.
Wiese KE, Haikala HM, von Eyss B, Wolf E, Esnault C, Rosenwald A, Treisman R, Klefström J, Eilers M.
Repression of SRF target genes is critical for Myc-dependent apoptosis of epithelial cells. The EMBO journal 11:1554-71, 2015.
Werner S, Brors B, Eick J, Marques E, Pogenberg V, Parret A, Kemming D, Wood AW, Edgren H, Neubauer H, Streichert T, Riethdorf S, Bedi U, Baccelli I, Jücker M, Eils R, Fehm T, Trumpp A, Johnsen SA, Klefström J, Wilmanns M, Müller V, Pantel K, Wikman H.
Suppression of early hematogenous dissemination of human breast cancer cells to bone marrow by retinoic Acid-induced 2. Cancer discovery 5:506-19, 2015.

2014

Hickman JA, Graeser R, de Hoogt R, Vidic S, Brito C, Gutekunst M, van der Kuip H, IMI PREDECT Consortium..
Three-dimensional models of cancer for pharmacology and cancer cell biology: capturing tumor complexity in vitro/ex vivo. Biotechnology journal 9:1115-28, 2014.

2013

Khanna A, Kauko O, Böckelman C, Laine A, Schreck I, Partanen JI, Szwajda A, Bormann S, Bilgen T, Helenius M, Pokharel YR, Pimanda J, Russel MR, Haglund C, Cole KA, Klefström J, Aittokallio T, Weiss C, Ristimäki A, Visakorpi T, Westermarck J.
Chk1 targeting reactivates PP2A tumor suppressor activity in cancer cells. Cancer research 22:6757-69, 2013.
Partanen JI, Tervonen TA, Klefström J.
Breaking the epithelial polarity barrier in cancer: the strange case of LKB1/PAR-4. Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1629:20130111, 2013.
Nieminen AI, Eskelinen VM, Haikala HM, Tervonen TA, Yan Y, Partanen JI, Klefström J.
Myc-induced AMPK-phospho p53 pathway activates Bak to sensitize mitochondrial apoptosis. Proceedings of the National Academy of Sciences of the United States of America 20:E1839-48, 2013.

2012

Partanen JI, Klefstrom J.
Impact of epithelial organization on Myc expression and activity–letter. Cancer research 4:1035; author reply 1036, 2012.
Partanen JI, Tervonen TA, Myllynen M, Lind E, Imai M, Katajisto P, Dijkgraaf GJ, Kovanen PE, Mäkelä TP, Werb Z, Klefström J.
Tumor suppressor function of Liver kinase B1 (Lkb1) is linked to regulation of epithelial integrity. Proceedings of the National Academy of Sciences of the United States of America 7:E388-97, 2012.

2011

Tervonen TA, Partanen JI, Saarikoski ST, Myllynen M, Marques E, Paasonen K, Moilanen A, Wohlfahrt G, Kovanen PE, Klefstrom J.
Faulty epithelial polarity genes and cancer. Advances in cancer research :97-161, 2011.

2010

Kyrönlahti A, Kauppinen M, Lind E, Unkila-Kallio L, Butzow R, Klefström J, Wilson DB, Anttonen M, Heikinheimo M.
GATA4 protects granulosa cell tumors from TRAIL-induced apoptosis. Endocrine-related cancer 3:709-17, 2010.
Jääskeläinen M, Nieminen A, Pökkylä RM, Kauppinen M, Liakka A, Heikinheimo M, Vaskivuo TE, Klefström J, Tapanainen JS.
Regulation of cell death in human fetal and adult ovaries–role of Bok and Bcl-X(L). Molecular and cellular endocrinology 1-2:17-24, 2010.

2009

Rajecki M, af Hällström T, Hakkarainen T, Nokisalmi P, Hautaniemi S, Nieminen AI, Tenhunen M, Rantanen V, Desmond RA, Chen DT, Guse K, Stenman UH, Gargini R, Kapanen M, Klefström J, Kanerva A, Pesonen S, Ahtiainen L, Hemminki A.
Mre11 inhibition by oncolytic adenovirus associates with autophagy and underlies synergy with ionizing radiation. International journal of cancer 10:2441-9, 2009.
Partanen JI, Nieminen AI, Klefstrom J.
3D view to tumor suppression: Lkb1, polarity and the arrest of oncogenic c-Myc. Cell cycle (Georgetown, Tex.) 5:716-24, 2009.

2008

Heinonen H, Nieminen A, Saarela M, Kallioniemi A, Klefström J, Hautaniemi S, Monni O.
Deciphering downstream gene targets of PI3K/mTOR/p70S6K pathway in breast cancer. BMC genomics :348, 2008.

2007

Nieminen AI, Partanen JI, Klefstrom J.
c-Myc blazing a trail of death: coupling of the mitochondrial and death receptor apoptosis pathways by c-Myc. Cell cycle (Georgetown, Tex.) 20:2464-72, 2007.
Partanen JI, Nieminen AI, Mäkelä TP, Klefstrom J.
Suppression of oncogenic properties of c-Myc by LKB1-controlled epithelial organization. Proceedings of the National Academy of Sciences of the United States of America 37:14694-9, 2007.
Nieminen AI, Partanen JI, Hau A, Klefstrom J.
c-Myc primed mitochondria determine cellular sensitivity to TRAIL-induced apoptosis. The EMBO journal 4:1055-67, 2007.

2003

Klefström J, Alitalo K.
[Lentiviruses to use]. Duodecim; laaketieteellinen aikakauskirja 20:1917-9, 2003.

2002

Klefstrom J, Verschuren EW, Evan G.
c-Myc augments the apoptotic activity of cytosolic death receptor signaling proteins by engaging the mitochondrial apoptotic pathway. The Journal of biological chemistry 45:43224-32, 2002.

1999

Klefstrom J, Kovanen PE, Somersalo K, Hueber AO, Littlewood T, Evan GI, Greenberg AH, Saksela E, Timonen T, Alitalo K.
c-Myc and E1A induced cellular sensitivity to activated NK cells involves cytotoxic granules as death effectors. Oncogene 13:2181-8, 1999.

1998

Kinnula VL, Aito H, Klefstrom J, Alitalo K, Raivio KO.
Similarities between TNF and exogenous oxidants on the cytotoxic response of c-Myc-expressing fibroblasts in vitro. Cancer letters 1-2:191-8, 1998.

1997

Klefstrom J, Arighi E, Littlewood T, Jäättelä M, Saksela E, Evan GI, Alitalo K.
Induction of TNF-sensitive cellular phenotype by c-Myc involves p53 and impaired NF-kappaB activation. The EMBO journal 24:7382-92, 1997.
Enholm B, Paavonen K, Ristimäki A, Kumar V, Gunji Y, Klefstrom J, Kivinen L, Laiho M, Olofsson B, Joukov V, Eriksson U, Alitalo K.
Comparison of VEGF, VEGF-B, VEGF-C and Ang-1 mRNA regulation by serum, growth factors, oncoproteins and hypoxia. Oncogene 20:2475-83, 1997.
Monni O, Joensuu H, Franssila K, Klefstrom J, Alitalo K, Knuutila S.
BCL2 overexpression associated with chromosomal amplification in diffuse large B-cell lymphoma. Blood 3:1168-74, 1997.

1994

Klefstrom J, Västrik I, Saksela E, Valle J, Eilers M, Alitalo K.
c-Myc induces cellular susceptibility to the cytotoxic action of TNF-alpha. The EMBO journal 22:5442-50, 1994.
Västrik I, Mäkelä TP, Koskinen PJ, Klefstrom J, Alitalo K.
Myc protein: partners and antagonists. Critical reviews in oncogenesis 1:59-68, 1994.
Knuutila S, Klefström J, Szymanska J, Lakkala T, Peltomäki P, Eray M, Teerenhovi L, Elonen E, Franssila KO, Kaartinen M.
Two novel human B-cell lymphoma lines of lymphatic follicle origin: cytogenetic, molecular genetic and histopathological characterisation. European journal of haematology 2:65-72, 1994.
Klefstrom J, Franssila K, Peltomäki P, Kaartinen M, Solin ML, Knuutila S.
Major and minor breakpoint sites of chromosomal translocation t(14;18) in subtypes of non-Hodgkin’s lymphomas. Leukemia research 4:245-50, 1994.

1993

Klefstrom J, Koskinen PJ, Saksela E, Jäättelä M, Bravo R, Alitalo K.
A sub-set of immediate early mRNAs induced by tumor necrosis factor-alpha during cellular cytotoxic and non-cytotoxic responses. International journal of cancer 4:655-9, 1993.

1992

Klefström J, Saksela E, Alitalo K.
[Complex mechanics of tumor-necrosis-factor-induced cell death]. Duodecim; laaketieteellinen aikakauskirja 17:1449-55, 1992.

1990

Klefström J, Kaartinen M, Peltomäki P, Solin ML, Franssila K, Knuutila S.
[The use of polymerase chain reaction in the diagnosis of non-Hodgkin’s lymphoma]. Duodecim; laaketieteellinen aikakauskirja 23-24:1645-53, 1990.

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