University of Helsinki
Klefström lab
Oncogenic signaling pathways as therapeutic targets in breast cancer
Our laboratory studies oncogene and tumor suppressor induced cancer-specific cellular programs, which cause therapeutic vulnerabilities in breast cancer.
Pharmacological intervention of SARS-CoV-2 entry mechanisms by blockade of TMPRSS activity
The Klefström laboratory has been identifying and developing chemical and pharmacological inhibitors against hepsin/TMPRSS family members for a long time with the goal of preventing cancer invasion. Some of our drugs or drug-like molecules could be repurposed to prevent SARS-CoV-2 entry to cells, potentially offering a fast-track treatment option for the COVID-19 disease.
Public Outreach – Follow our team!
Klefström lab on facebook
New insight from our research team to the fundamental question of what type of cellular programs cancer genes switch on to start the invasion process.![]()
www.helsinki.fi/en/news/health-news/a-master-cancer-gene-hijacks-a-molecular-crowbar-to-make-brea...
www.helsinki.fi
Researchers investigated how cancer genes lead to the breakdown of the capsule that prevents cancerous cells from invading the surrounding healthy tissues and - find a hijacked “molecular crowbar”.
Our group wishes you and your family comfort and joy this holiday season. ❄❄![]()
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#holidayseason #cancerresearch
Great science in great (mostly virtual) company. Today we discussed our plans for 2021, and it seems like we have many things to look forward to. ![]()
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#cancerresearch
University of Helsinki is highlighting one of Klefström lab's grad students, Rita Turpin, on their instagram page. We are happy to promote breast cancer awareness, as well as highlight our efforts to boost Finnish capabilities in cancer immunotherapy (cancerio.org). Rita will share snippets of her working day through the 'stories' feature on IG for the next 24hrs. #scicomm #breastcancerawareness
Klefström lab summer student summit 2020! Our summer students had their first opportunity to present what they have been up to. Great work, students and supervisors!