University of Helsinki
Klefström lab
Oncogenic signaling pathways as therapeutic targets in breast cancer
Our laboratory studies oncogene and tumor suppressor induced cancer-specific cellular programs, which cause therapeutic vulnerabilities in breast cancer.
Pharmacological intervention of SARS-CoV-2 entry mechanisms by blockade of TMPRSS activity
The Klefström laboratory has been identifying and developing chemical and pharmacological inhibitors against hepsin/TMPRSS family members for a long time with the goal of preventing cancer invasion. Some of our drugs or drug-like molecules could be repurposed to prevent SARS-CoV-2 entry to cells, potentially offering a fast-track treatment option for the COVID-19 disease.
Public Outreach – Follow our team!
Klefström lab on facebook
We feel privileged to have presented twice (a minisymposium and a poster session) at the annual AACR meeting. Thank you for joining us, and for the active Q and A session. We appreciate your curiosity and support.
#aacr2020
Great news! CancerIO is launching in Finland. 🥳
"The coming age of IO will have a transformative impact on fundamental and clinical cancer research, healthcare systems, business and, most importantly, on the lives of cancer patients."
Check out the whole article:
www.helsinki.fi/en/news/health-news/10-million-euros-investment-boosts-finnish-capabilities-in-ca...
Love and science moves in mysterious ways. We never thought that the protease family we have been investigating for 10 years and which helps breast cancer to invade healthy tissue - also critically helps coronavirus to enter the healthy cells. Luckily, we have pretty goods drugs in our pocket against these proteases (more info behind the link) 💪 Stay tuned!
Ps. Message to Finnish decision makers and University leadership - please keep the research labs open. Scientific research is the only rational way to solve the current health crisis for good. Let us work towards this goal (although none of us can predict from which scientific program the solution will come)!
www.helsinki.fi/en/researchgroups/covid-19/research