Klefström lab / Klefström lab

Klefström lab

Oncogenic signaling pathways as therapeutic targets in breast cancer

Our laboratory studies oncogene and tumor suppressor induced cancer-specific cellular programs, which cause therapeutic vulnerabilities in breast cancer.

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News

Lab Retreat 2017

The annual Klefström research group lab retreat took place in November 2017. The two-day lab retreat inspired scientific discussions and debates across a wide range of cancer-related topics. After the scientific presentations of the day, KlefaLab members unwinded with a friendly game of bubble soccer. Additional time was taken to acknowledge the strengths of each lab member with a light-hearted “award” ceremony.

 

 

Klefström lab on facebook

2 months ago

Klefström Research Group

Congratulations for Immunotherapy and therapists www.facebook.com/nobelprize/photos/a.164901829102/10155904302279103/?type=3&theaterBREAKING NEWS
The Nobel Assembly at Karolinska Institutet has today decided to award the 2018 Nobel Prize in Physiology or Medicine jointly to James P. Allison and Tasuku Honjo “for their discovery of cancer therapy by inhibition of negative immune regulation.”

Cancer kills millions of people every year and is one of humanity’s greatest health challenges. By stimulating the inherent ability of our immune system to attack tumour cells this year’s Nobel Laureates have established an entirely new principle for cancer therapy.

James P. Allison studied a known protein that functions as a brake on the immune system. He realised the potential of releasing the brake and thereby unleashing our immune cells to attack tumours. He then developed this concept into a brand new approach for treating patients.

In parallel, Tasuku Honjo discovered a protein on immune cells and, after careful exploration of its function, eventually revealed that it also operates as a brake, but with a different mechanism of action. Therapies based on his discovery proved to be strikingly effective in the fight against cancer.

Allison and Honjo showed how different strategies for inhibiting the brakes on the immune system can be used in the treatment of cancer. The seminal discoveries by the two laureates constitute a landmark in our fight against cancer.

Learn more: bit.ly/2OpzIIS
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Research Programs Unit/Translational Cancer Biology
& Medicum, Biomedicum Helsinki 1,
Medical Faculty, University of Helsinki

Haartmaninkatu 8
00290 Helsinki
FINLAND

University of Helsinki internal mailing address
P.O. Box 63
FI-00014 University of Helsinki
Finland

Tel. Lab +358 2 941 25494 (room B509)
Office +358 2 941 25493 (room B507b)
Junior office (room B503)
Fax +358 2 941 25610

firstname.surname@helsinki.fi